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In this study, B12 levels were 244 pmol/l or more in all patients at baseline, but in those who improved, B12 levels almost quadrupled, whilst in non-responders B12 levels went up by only 50%

11 However, GLP-1s alone are not a strategy they must be embedded within a broader obesity management framework that includes employer support through benefit design, clinical partnerships, behavioral programs and data-driven governance to ensure long-term adherence and meaningful health outcomes

Nausea peaks during the first 4-8 weeks and during dose escalations, then improves as the body adapts

Avoid high-sugar processed foods, carbonated beverages, and fried foods, which can trigger nausea more easily on semaglutide

On average, GLP-1 RA reduced BMI (SMD 0.67

U., et al